AutoHotkey Community

I have looked everywhere and could not find anything doing this or tellnig how to do it. Can I assign a hotkey to something using two letters + other key combo, such as, Windows key+Ctrl+r+a for one hotkey and windows key+Ctrl+r+b for another.

Try using ampersand "&"
http://www.autohotkey.com/docs/Hotkeys.htm

...but there are physical limitations: some keyboards (e.g. Dell) cannot detect certain multiple key presses. It is safer to use key combinations, when you release the first key. It can be done with If GetKeyState("KeyName") -like cases inside the first hotkey routine.

chaining together with ampersand doesn't work. Can you give me a small example script laszlo.

Actually, Input is better than GetKeyState

Thanks that little script helped me figure out what I am going to use.
#^r::
Input, userKey, I L2
If userKey = bs

So the user hits the hotkey then can type bs to run the macro.
I can add different strings to each hotkey to free up a lot of different options.

I just experimented with combination keys like the following.

Pressing 'y' and 'u' simultaneously shows the msgbox, but now my 'y' key does nothing when pressed singly. Am I running into what Laszlo wrote below? I have an IBM keyboard plugged into a Dell port replicator.

The problem is that your y key is now a prefix key with different behavior. You can define actions for it, but it won't aouto-repeat, Shift, CapsLock behaves differently with it, so it is better not to use this kind of combinations with normal keyboard keys.

I can't answer your question, but try the following:

From the Helpfile:

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2) Intuitive. Logical. Versatile. Adaptable. <<AutoHotkey>>