CS-Script can now be modified to run JScript .NET and VB.NET . The author said he would make these options the default behavior in the upcoming release.
Another program that is somewhat similar and can run/compile JScript .NET, C#, and VB.NET is NScript (
http://www.codeproject.com/dotnet/nscript.asp )
I now there are some anti-.NET people out there, but the Mono (
http://www.mono-project.com/Main_Page ) and DotGNU Portable .NET (
http://www.dotgnu.org/pnet.html ) projects have come a long way and make it possible to run many .NET application on the Linux and MAC platform. Add that many XP service pack 2 computers have the .NET framework already on them and the new Windows Vista will have the .NET framework too and the picture should be obvious. .NET is here to stay.
What's great about CS-Script and NScript is that you can use FileAppend and other methods to run JScript, C#, and VB.NET code from AutoHotkey.