With this little script you can control the Media Keys with the mouse (no Media Keyboard required).
System Requirements: Windows NT/2000/XP.
Hotkeys:
Win + Left Button : Play / Pause
Win + Right Button : Stop
Win + Middle Button (wheel) : Mute / UnMute
Win + Scroll Up : Volume Up
Win + Scroll Down : Volume Down
Win + Forward Button : Next
Win + Back Button : Previous
#LButton:: SendInput, {Blind}{Media_Play_Pause} Return #RButton:: SendInput, {Blind}{Media_Stop} Return #MButton:: SendInput, {Blind}{Volume_Mute} Return #WheelUp:: SendInput, {Blind}{Volume_Up} Return #WheelDown:: SendInput, {Blind}{Volume_Down} Return #XButton1:: SendInput, {Blind}{Media_Prev} Return #XButton2:: SendInput, {Blind}{Media_Next} Return
[/Herby]